Progesterone Receptor
NR3C3
Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.
Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.
In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).
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Progesterone Receptor Inhibitors
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Progesterone Receptor Agonists
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Progesterone Receptor Antagonists
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Progesterone Receptor Activators
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Progesterone Receptor Modulators
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Progesterone Receptor Ligands
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Progesterone Receptor Proteins
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Progesterone Receptor Related Products (161)
Related Products (161)
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Recombinant Proteins (1)
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Antibodies (2)
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Norethindrone (Standard)
0 ImagesNorethindrone (Standard) is the analytical standard of Norethindrone. This product is intended for research and analytical applications. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
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Mifepristone-d3
0 ImagesCat. No.: HY-13683SSynonyms: RU486-d3; RU 38486-d3Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
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Mifepristone-d6
0 ImagesSynonyms: RU486-d6; RU 38486-d6Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
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Progesterone-13C3
0 ImagesSynonyms: Pregn-4-ene-3,20-dione-13C3Progesterone-13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
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PF-3882845
0 ImagesPF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM.
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Norgestomet
0 ImagesNorgestomet is a synthetic 19-nortestosterone-derived progestin analog specifically used for estrus synchronization and reproductive regulation in cattle. Norgestomet reduces the incidence of short luteal phases in postpartum lactating beef cattle, enhances luteal function, and increases the pregnancy rate of timed breeding. Norgestomet suppresses estrus during embryo implantation, synchronizes the timing of estrus resumption, and improves the calving rate of first timed artificial insemination in pubertal beef heifers.
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17α-Hydroxyprogesterone-13C3
0 ImagesCat. No.: HY-B0891S1CAS No.: 1356154-92-1Synonyms: 17-Hydroxyprogesterone-13C3; 17-OHP-13C3
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Medroxyprogesterone-d3
0 ImagesCat. No.: HY-B0648SCAS No.: 162462-69-3Synonyms: 17α-Hydroxy-6α-methylprogesterone-d3; U8840-d3Medroxyprogesterone-d3 is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
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Melengestrol acetate (Standard)
0 ImagesMelengestrol acetate (Standard) is the analytical standard of Melengestrol acetate. This product is intended for research and analytical applications. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
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Drospirenone-d4
0 ImagesCat. No.: HY-B0111SCAS No.: 2376035-94-6Synonyms: Dihydrospirorenone-d4Drospirenone-d4 is the deuterium labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
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Dienogest (Standard)
0 ImagesSynonyms: STS 557 (Standard)Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.
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Progesterone-13C2
0 ImagesSynonyms: Pregn-4-ene-3,20-dione-13C2Progesterone-13C2 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
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Progesterone-13C5
0 ImagesCat. No.: HY-N0437S1CAS No.: 2687960-32-1Synonyms: Pregn-4-ene-3,20-dione-13C5Progesterone-13C5 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
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Megestrol acetate-d3
0 ImagesCat. No.: HY-13676SCAS No.: 162462-72-8Megestrol acetate-d3 is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.
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Mifepristone-13C,d3
0 ImagesCat. No.: HY-13683S1Synonyms: RU486-13C,d3; RU 38486-13C,d3Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Dienogest-d6
0 ImagesCat. No.: HY-B0084S2Purity: 99.92%Synonyms: STS 557-d6Dienogest-d6 is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis.
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WAY-255348
0 ImagesCat. No.: HY-12073CAS No.: 872141-23-6W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer.
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Hydroxyprogesterone Caproate-d11
0 ImagesCat. No.: HY-W750386Synonyms: 17α-Hydroxyprogesterone hexanoate-d11; 17α-Hydroxyprogesterone caproate-d11Hydroxyprogesterone Caproate-d11 (17α-Hydroxyprogesterone hexanoate-d11; 17α-Hydroxyprogesterone caproate-d11) is the deuterium labeled Hydroxyprogesterone caproate (HY-B0742). Hydroxyprogesterone caproate is a synthetic progestin, a steroid.
