2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Progesterone Receptor

Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16775
    Vilaprisan
    		Modulator 99.75%
    Vilaprisan is a selective progesterone receptor modulator (SPRM), which targets progesterone receptors. Vilaprisan can inhibit cell proliferation and stimulate apoptosis. Vilaprisan has oral efficacy and anti-proliferative activity against uterine leiomyoma (UF).
    Vilaprisan
  • HY-B0554R
    Norethindrone (Standard)
    		Agonist
    Norethindrone (Standard) is the analytical standard of Norethindrone. This product is intended for research and analytical applications. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
    Norethindrone (Standard)
  • HY-13683S
    Mifepristone-d3
    		Antagonist
    Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
    Mifepristone-d<sub>3</sub>
  • HY-13683S2
    Mifepristone-d6
    		Antagonist 98.21%
    Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
    Mifepristone-d<sub>6</sub>
  • HY-N0437S2
    Progesterone-13C3
    		Agonist 99.60%
    Progesterone-13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-<sup>13</sup>C<sub>3</sub>
  • HY-12738
    PF-3882845
    		Antagonist 99.90%
    PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM.
    PF-3882845
  • HY-121677
    Norgestomet
    		Agonist 98.16%
    Norgestomet is a compound with progesterone receptor agonist activity. The synthetic product has high purity and agonist activity on the progesterone receptor, while its 17β-isomer is inactive.
    Norgestomet
  • HY-B0891S1
    17α-Hydroxyprogesterone-13C3
    		Agonist 98.9%
    17α-Hydroxyprogesterone-13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
    17α-Hydroxyprogesterone-<sup>13</sup>C<sub>3</sub>
  • HY-B0648S
    Medroxyprogesterone-d3
    		Agonist
    Medroxyprogesterone-d3 is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
    Medroxyprogesterone-d<sub>3</sub>
  • HY-111614R
    Melengestrol acetate (Standard)
    		Activator
    Melengestrol acetate (Standard) is the analytical standard of Melengestrol acetate. This product is intended for research and analytical applications. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate (Standard)
  • HY-B0111S
    Drospirenone-d4
    		Agonist 98.52%
    Drospirenone-d4 is the deuterium labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
    Drospirenone-d<sub>4</sub>
  • HY-B0084R
    Dienogest (Standard)
    		Agonist
    Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.
    Dienogest (Standard)
  • HY-N0437S3
    Progesterone-13C2
    		Agonist 99.7%
    Progesterone-13C2 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-<sup>13</sup>C<sub>2</sub>
  • HY-N0347
    17α-Hydroxyprogesterone acetate
    		99.75%
    17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface.
    17α-Hydroxyprogesterone acetate
  • HY-N0437S1
    Progesterone-13C5
    		Agonist
    Progesterone-13C5 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-<sup>13</sup>C<sub>5</sub>
  • HY-13676S
    Megestrol acetate-d3
    		Inhibitor
    Megestrol acetate-d3 is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.
    Megestrol acetate-d<sub>3</sub>
  • HY-13683S1
    Mifepristone-13C,d3
    		Antagonist
    Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mifepristone-<sup>13</sup>C,d<sub>3</sub>
  • HY-B0084S2
    Dienogest-d6
    		Agonist 99.92%
    Dienogest-d6 is deuterium labeled Dienogest (HY-B0084). Dienogest is an orally active progesterone receptor agonist that can be used in the study of endometriosis.
    Dienogest-d<sub>6</sub>
  • HY-12073
    WAY-255348
    		Antagonist
    W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer.
    WAY-255348
  • HY-W750386
    Hydroxyprogesterone Caproate-d11
    Hydroxyprogesterone Caproate-d11 (17α-Hydroxyprogesterone hexanoate-d11; 17α-Hydroxyprogesterone caproate-d11) is the deuterium labeled Hydroxyprogesterone caproate (HY-B0742). Hydroxyprogesterone caproate is a synthetic progestin, a steroid.
    Hydroxyprogesterone Caproate-d<sub>11</sub>
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity